“The precise mechanism by which the medicine works is unknown.” This is what is written in the drug information sheet for Seroquel, the second antipsychotic my son was put on. The drug manufacturer says, “This is a major area of research. One belief is that psychotic symptoms are related to over activity in the brain of the neurotransmitter dopamine. It is thought that antipsychotic medications reduce the activity of dopamine in the synaptic cleft. They do this by blocking the dopamine receptors—that is, preventing dopamine from attaching to the receptors. These medicines may also affect several other neurotransmitters in the brain, such as serotonin, norepinephrine, and glutamate. The overall purpose of anti-psychotic treatment is to restore the disturbed chemical balance of the brain.”
The hypothesis about the schizophrenic brain containing an excessive number of dopaminergic receptors explains some of the effects of the antipsychotics. It explains that when the dopaminergic receptors get blocked, the symptoms improve. It also explains how the antipsychotic drugs control behaviors but don’t cure schizophrenia. As soon as they are eliminated from the body, the receptors become free, and an excessive number of them start producing the schizophrenic pathology again (Mackliff, 2012).
Since 75 percent of young people diagnosed with schizophrenia stop taking the medicine during the first year and half of treatment because the side effects are so intolerable, the schizophrenic pathology begins again and again (New York State Mental Health, 2015).
The antipsychotic effect on schizophrenic patients hospitalized for a long time implies a permanent action on the cerebral synapses. The antipsychotic drug alters the capacity of the cell to respond to the synaptic impulse and furthermore alters its capacity to transmit information to other nervous cells. (Mackliff D. J., 2016)
Antipsychotics and BEAM
The benefits of BEAM surgery in Parkinson’s patients are immediate, in schizophrenic patients after two to three days. It is also important to understand that BEAM is a surgery that produces synaptic changes, signal transmission rate change, and genetic change. It helps to avoid antipsychotic increases in dopamine receptors in the limbic area because, after the operation, biochemical changes in the brains of schizophrenics occur immediately. The patient and his or her family need to work with the psychological effects of the patient’s recovery, and this takes time.
BEAM produces a change that antipsychotic drugs cannot perform, but antipsychotics in the indicated doses work perfectly on a schizophrenic patient who maintains a different synaptic plasticity, which he or she did not have before the BEAM operation.